CLIC1 and neoplasm: Based on our previous experimental studies and on the findings of the present research, CLIC1 released by tumor cells and tumor emboli inside tumor blood vessels represent strong evidence of its angiogenic effect, supported by the presence inside the tumor and in peritumor area of small and well-defined blood vessels lining the CLIC1-positive endothelium, with a vascular morphology highly suggestive of an intense angiogenic process.