Significant correlations between CLIC1-MVD and TNM staging parameters, as well as the microscopic presence of CLIC1-positive tumor emboli inside tumor blood vessels lined by a CLIC1-positive endothelium, support the angiogenic role of CLIC1 secreted by the tumor cells, while also confirming its involvement as a promoter of cancer progression and metastasis. Here, CLIC1 is linked to cancer.