It is of interest to note that Maffei et al. previously reported that monocytes from normal donors, cultured with CLL-cm, released higher amounts of IL-10, IL-8 and IL-6, thus, suggesting that both paracrine (from CLL B cells) and autocrine (from monocytes) IL-10 secretion may contribute in enhancing CD16 expression as well as osteoclastogenesis [32]. The gene discussed is CXCL8; the disease is B-cell chronic lymphocytic leukemia.