In addition, we demonstrated that healthy monocytes, pre-activated with either IL-10, TGFβ or CLL-cm, gave rise to a higher proportion of mature osteoclasts, characterized by a larger size (BIG), significantly evident for the aforementioned cytokines and in a trend mode for CLL-cm (Figure 6B,C). This evidence concerns the gene IL10 and B-cell chronic lymphocytic leukemia.