Here, compared to controls, SNP rs28929474 was more frequent in the CCA group (4.1% vs. 1.7%; OR = 2.46, 95% CI = 1.14–5.32; p = 0.036), suggesting that SERPINA1 rs28929474 is associated with an increased risk of CCA. The gene discussed is SERPINA1; the disease is cholangiocarcinoma.