Interferon gamma (IFNG, encoding IFN-γ) rs2430561 AA genotype was also associated with CCA when the APF− and CCA groups were compared (OR = 2.20, p < 0.05) indicating that this particular genotype might cause the observed decrease in IFN-γ (Figure S1) [52]. This evidence concerns the gene IFNG and cholangiocarcinoma.