CD8A and neoplasm: Naïve CD3+T cells recruited by TLSs become activated, proliferate, and differentiate based on the local tumor antigen presentation, cytokine milieu, and expression of costimulatory molecules, to result in several subsets of effector CD4+ T helper cells (Th), effector CD8+ T cytotoxic cells (CTL), and a small amount of memory T cells (Tm).