The up-regulated gene expression of CXCL13 has been proven to be associated with better prognosis in oral cancer, bladder cancer, and ovarian cancer [11,14,61], and CXCL13 was significantly lower in patients with metastatic thyroid cancers, which was associated with an abundance of inefficient Tfh cells [62]. The gene discussed is CXCL13; the disease is lip and oral cavity carcinoma.