For patients with sporadic disease, different studies focused on uncommon germline variants associated with NB have been conducted, and pathogenic and likely pathogenic variants were identified in predisposition genes such as ALK, CHEK2, BRCA2, SMARCA4, and TP53 and in candidate genes such as AXIN2, PALB2, BARD1, PINK1, APC, BRCA1, SDHB, and LZTR1 [20,22,171,172,173,174]. This evidence concerns the gene ALK and neuroblastoma.