This review summarizes the immune checkpoint and other receptor-ligand interaction between macrophages and tumor cells, which plays an indispensable role in anti-tumor immunity or pro-tumor immunity, such as SIRPα-CD47, PD1-PD-L1, FcγR-Antibody-Antigen, CSF-1/CSF-1R axis. The gene discussed is CD47; the disease is neoplasm.