More recently, Sally et al. identified a cell surface metadherin/CEACAM1-CCL3 positive feedback loop that can increase the formation of polyploid tumor cells and limit the efficacy of therapies in an isogenic tumor cell pair model of highly metastatic (HM) and non-metastatic (NM) tumor cells that resemble the spontaneous human ovarian cancer metastasis model. This evidence concerns the gene MTDH and neoplasm.