SYK and neoplasm: Accordingly, the tyrosine residues in the ITAM will be phosphorylated by SRC family kinases, which results in the recruitment and activation of the spleen tyrosine kinase (SYK) family, which transduces downstream signals that eventually lead to actin cytoskeleton rearrangement, the formation of phagocytic synapses between macrophages and tumor cells, and phagocytosis of target cells [12].