Significantly, as a homotypic receptor, SLAMF7 on macrophages can bind to SLAMF7 on cancer cells and act synergistically with macrophage-1 (MAC1) antigen, which is known to interact with two ITAM-containing receptors, FcRγ and DAP12 [37], and then induce cytoskeletal reorganization to phagocytosis tumor cells through SRC kinase, SYK, and BTK, rather than enhancing adhesion to targets cells [38]. This evidence concerns the gene SLAMF7 and cancer.