BRCA1 and gastric cancer: However, H. pylori is a well-documented GC risk factor that is treatable, and as with other hereditary GC risk syndromes, such as Lynch syndrome, we believe that it would be reasonable to test for H. pylori (either non-invasively or via gastric biopsy) among BRCA1/2 PV carriers at least one-time, with treatment and confirmation of eradication if H. pylori is present.