In a 2012 study by Moran et al. [23] involving 268 BRCA1-associated families in England, risk of GC was increased in BRCA1-positive families compared to the general population (RR 2.4, 95% CI 1.2–4.3), although notably this risk was driven by GC diagnosed among 1184 potential BRCA1 PV carriers that had not undergone BRCA1/2 testing. Here, BRCA1 is linked to gastric cancer.