BRCA1 and cancer: In a 2004 study by Bermejo et al. [49] among families with at least three generations in the Swedish Family-Cancer Database that met eligibility criteria for BRCA1 or BRCA2 PV testing (n = 130,487), development of GC by age 70 occurred twice as frequently in families with breast and ovarian cancer (1.88%, 95% CI 1.05–3.12%) compared to the general population (0.92%).