BRCA2 and cancer: Several years later, the aforementioned 2010 study by Schlebusch et al. [26] examining cancer prevalence among South African breast-ovarian cancer families revealed that prevalence of GC was increased among 43 families (n = 1264 relatives) with a BRCA2 PV compared to the general population (24 cases observed vs. 11.17 expected, p = 0.0001).