BRCA1 and cancer: More recently in 2022, Li et al. [15] examined cancer risk among 3184 families in the multinational Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA) with at least one family member having a BRCA1 PV, noting increased risk of GC among 8884 BRCA1 PV carriers (RR 2.17, 95% CI 1.25–3.77), particularly including those less than 65 years old (RR 3.50, 95% CI 2.01–6.10).