BRCA1 and cancer: In a 1999 study by Johannsson et al. [27] examining the incidence of malignant tumors in 29 Swedish families (n = 1145 relatives) with a proband carrying a germline BRCA1 PV, incidence of GC was increased among all individuals (standardized morbidity rate (SMR) 2.76, 95% CI 1.01–6.00) and women in isolation (SMR 5.16, 95% CI 1.14–13.22), but not among men (SMR 1.43, 95% CI 0.17–5.15).