For breast cancer surveillance, National Comprehensive Cancer Network (NCCN) guidelines recommend that female BRCA1/2 PV carriers are taught breast awareness at age 18 and undergo clinical breast exams every 6–12 months starting at age 25, annual breast magnetic resonance imaging (MRI) from age 25–30, and annual mammogram and breast MRI from age 30–75, supplemented with discussion of the option of risk-reducing mastectomy [71]. The gene discussed is BRCA1; the disease is breast cancer.