Likewise, a 2010 study by Schlebusch et al. [26] involving South African families with history of breast and/or ovarian cancer noted that risk of GC was not increased among 26 families (n = 793 relatives) with a BRCA1 PV compared to the general population (7 cases observed vs. 6.62 expected, p = 0.8829). The gene discussed is BRCA1; the disease is gastric cancer.