IGF2BP3 and malignant colon neoplasm: We first analyzed the relative mRNA expression level of IGF2BP3 in four human colon cancer cell lines (HCT116, HT29, SW480 and LoVo) and found that the mRNA expression level of IGF2BP3 was significantly higher in SW480 than that in the normal human colon cell line NCM460 (Figure 6C), so we chose SW480 for subsequent experiments in vitro.