Similarly, the expression of TGFβR2 in colon or breast carcinomas showed growth inhibition, suppression of anchorage independence, and reduced tumor formation and metastasis in vivo [69] whereas dominant negative TGFβR2 abolished the ability of TGFβ to inhibit cell growth, to promote cell differentiation, and to induce apoptosis [70]. This evidence concerns the gene TGFB1 and breast carcinoma.