The analysis of PHLPP phosphatases mRNA expression showed that prolonged insulin stimulation of HEC-1A cells caused both in hypoglycemia and hyperglycemia conditions to a decrease in PHLPP1 and increase in PHLPP2 after 4 h stimulation and then the level was similar to in control cells (Figure 4A). This evidence concerns the gene PHLPP1 and Hyperglycemia.