In addition, several well-known PID-related genes are recognized as cancer-predisposing genes, including those found in immune dysregulation (e.g., ITK, KRAS), combined immunodeficiencies (e.g., JAK3, RECQL4) and phagocytic disorders (e.g., CDKN2A, CSF3R) [2]. The gene discussed is CSF3R; the disease is cancer.