In vitro experiments have revealed that TrMab-6 strongly induces antibody-dependent cellular cytotoxicity and complement-dependent cytotoxicity activities in mouse xenograft models of Trop-2-overexpressing CHO-K1 and breast cancer cell lines (MCF7, MDA-MB-231, and MDA-MB-468). The gene discussed is TACSTD2; the disease is breast carcinoma.