The phase I ASSET trial is enrolling patients with metastatic TNBC to evaluate the combination of sacituzumab govitecan plus alpelisib, a PI3K inhibitor, initially approved in combination with fulvestrant for use in patients with metastatic HR+ HER2- breast cancer, based on the results of the SOLAR-1 trial. The gene discussed is ERBB2; the disease is breast carcinoma.