Other mechanisms include regulating cancer cell metabolism, regulating the immune environment, regulating growth factor secretion, targeting Akt and mTOR pathways, regulating skeletal muscle IL-6, and improving mitochondrial function which can inhibit cancer cell proliferation as well as apoptosis, though only moderate intensity exercise appears to exert significant influence on cancer cell proliferation and apoptosis [162]. This evidence concerns the gene AKT1 and cancer.