This is also supported by proteomics data which has shown that EGFRvIII-expressing glioma cells secrete greater numbers and levels of invasion-promoting proteins compared to wild-type EGFR glioma cells, such as increased expression of MMP-2 and the protease cathepsin B [120], both of which are responsible for ECM remodelling and cell invasion. Here, CTSB is linked to glioma.