MMP9 and neoplasm: It has been well characterised that EGFR and FAK activation promote cell invasion through increased expression of matrix metalloproteinases (MMP), particularly MMP-2 (gelatinase-A) and MMP-9 (gelatinase-B) [99,102,103,104], as well as other proteases [105], which are proteolytic enzymes that degrade proteins within the ECM to facilitate tumour cell migration and invasion.