HIF1A and leukemia: On the other hand, miR-210 secreted from leukemia cell lines induces tubulogenesis [144]; miR-135b inhibits FIH-1 (Factor Inhibiting HIF-1) and stimulates endothelial tube formation [133]; miR-494 from lung cancer cells targets PTEN, activating the AKT/eNOS pathway and resulting in enhanced angiogenesis; and miR-23a promotes angiogenesis by targeting prolyl hydroxylase and thus avoiding the degradation of HIF-1α [145].