TGFB1 and prostate cancer: Finally, TGFβ1 produced by platelets in prostate cancer seems to affect the osteoclastogenesis/osteoblastogenesis balance, resulting in bone lesions that favor the development of a premetastatic microenvironment [70].Although many of these studies do not directly describe the role of TGFβ secreted by the primary tumor, they do seem to suggest that if TGFβ from other sources can have such a high impact on premetastatic niche formation, it could be expected that TGFβ secreted in response to hypoxia could act similarly, making it an interesting avenue for future research.