The entire set of risk predictors was composed by the mutational status of TP53, SMAD4, and FBXW7, plus the clinical variables age, sex, ECOG performance status, number of affected organs (one or more), MSI status, location of the primary tumor (right or left), LDH, ALP, leukocytes in blood, and PCR levels. This evidence concerns the gene TP53 and neoplasm.