PCNA and familial pancreatic carcinoma: In addition, we uncovered the critical role of FTO in pancreatic cancer cell proliferation and demonstrated that knockdown of FTO led to cell cycle arrest in the G1 phase, and increment in the expression of cyclin/CDK inhibitors, p21cip1 and p27Kip1, which in turn was reflected in their impaired ability to survive and grow as a tumor in a xenograft mice model.