Further relevance of our findings is strengthened by the demonstration in low-FTO expressing normal HPDE cells, wherein ectopic restoration of FTO expression confers potential oncogenic phenotype, scrutinized in terms of enhanced proliferative and migratory advantage and conversion of epithelial-to-mesenchymal features, a significant phenomenon associated with tumor initiation and metastasis [50]. The gene discussed is FTO; the disease is neoplasm.