Based on these correlations and the literature data, we propose a simplified signalling scheme of preferential targeting of GSCs cells via antagonizing GPR55 and inversely agonizing TRPV1 receptors, which are on one hand both highly expressed in GSCs and on the other correlate with several major GBM stemness genes (CD15, SOX2, OLIG4, NOTCH, and ID1). This evidence concerns the gene SOX2 and glioblastoma.