Thus, the aim of this study is to detect the localization of CNTF and CNTFRα in androgen-sensitive and androgen-insensitive human PCa tissues and to analyze the possible role of CNTF in signaling-pathway modulation involved in glucose uptake, proliferation, migration and invasion processes using sensitive (LNCaP) and androgen-insensitive (22Rv1) cell lines. This evidence concerns the gene CNTF and posterior cortical atrophy.