PECAM1 and melanoma: Immunostaining using the vascular endothelial cell marker (CD31) or lymphatic endothelial cell marker (LYVE-1) of in vivo Matrigel plugs revealed that plugs were well vascularized for the MeWo cells (Figure 5A(b,c)), A375 cells (Figure 5B(h,i)), and SK-MEL-28 cells (Figure 5C(n,o)), suggesting the capacity of the melanoma cells to recruit vascular and lymphatic endothelial cells to develop and intensify angiogenesis and lymphangiogenesis, respectively.