PECAM1 and melanoma: Quantification of CD31-positive endothelial cells and LYVE-1 positive lymphatic cells demonstrated a marked decrease in the number of both cell types in plugs from animals treated with αAMRs compared to animals treated with control-IgG (p < 0.01; p < 0.001; Figure 5D–F) These data strongly suggest that a part of the angiogenesis and lymphangiogenesis revealed in plugs is due to AM secreted by melanoma cells.