In particular, STAT3 suppresses the effects of anti-tumor Th1 cytokines, such as IL-12, IFN-γ, and induces secretion of tumorigenic mediators (e.g., cytokines, pro-angiogenic and growth factors) while promoting the expression of corresponding receptors that, in turn, induce a STAT3 mediated immunoregulatory circuit in the TME [131]. Here, STAT3 is linked to neoplasm.