Among non-NF2 meningiomas, key driver mutations involve Kruppel-like factor 4 (KLF4), v-Akt murine thymoma viral oncogene homolog 1 (AKT1), tumor necrosis factor receptor-associated factor 7 (TRAF7), phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA), smoothened (SMO) and RNA polymerase II subunit A (POLR2A) [22,27,104,105]. This evidence concerns the gene KLF4 and meningioma.