Because a number of adenocarcinomas express MUC16, and adenocarcinomas represent one of the most common carcinomas metastasizing to the leptomeninges, it is conceivable that an interaction with meningioma mesothelin and mucins facilitates anchoring by adenocarcinoma metastasis to meningiomas [28,32] (Figure 3). This evidence concerns the gene MUC16 and adenocarcinoma.