Because a number of adenocarcinomas express MUC16, and adenocarcinomas represent one of the most common carcinomas metastasizing to the leptomeninges, it is conceivable that an interaction with meningioma mesothelin and mucins facilitates anchoring by adenocarcinoma metastasis to the leptomeninges and meningiomas In the peritoneum, mesothelin serves as an anchoring site for metastatic adenocarcinoma cells by binding MUC16 [27,29]. The gene discussed is MUC16; the disease is adenocarcinoma.