Among AJ, renal cancer (for either sex) and melanoma (in males only) were noted at a higher prevalence among APC I1307K carriers compared with healthy individuals [OR 1.64 (95% CI 1.04–2.47) and OR 2.04 (95% CI 1.24–3.22); p < 0.05, respectively (Figure 2)]. The gene discussed is APC; the disease is renal carcinoma.