APC and cancer: Overall, 586/7624 (7.6%) AJ with any cancer carried the I1307K APC variant compared to 342/4918 (6.9%) in the AJ control group (p = NS) (Figure 2); however, among AJ males with any cancer, the rate of I1307K APC was significantly higher than in AJ males without cancer [OR 1.32 (95% CI 1.05–1.66), p < 0.05].