Woodage and colleagues [13] reported a higher overall cancer risk, excluding non-melanoma skin cancer in AJ carrying the APC I1307K variant (OR 1.5, 95% CI 1.1–2.0, p = 0.01) and a higher frequency of breast cancer in first-degree relatives (OR 1.4, 95% CI 1.1–1.8, p = 0.01). Here, APC is linked to cancer.