HBEGF and ovarian cancer: Ovarian cancer patients showed significantly higher concentrations of both Nectin-4 (median: OvCa patients: 137.7 pg/mL, control: 0 pg/mL, p < 0.0001) and HB-EGF (median: OvCa patients: 16.4 pg/mL, control: 9.4 pg/mL, p = 0.016) compared to the control cohort (Figure 1A,B).