MiR-101 binds to the 3′-UTR of tribbles pseudokinase 1 (TRIB1) mRNA, leading to increased transcription and secretion of interleukin-8 to regulate macrophage 2 differentiation in prostate cancer and control the inflammatory profile of human primary macrophages and prostate cancer cells [128]. This evidence concerns the gene CXCL8 and Familial prostate cancer.