Melanoma tumorigenesis and progression has been linked to dysregulation of epigenetic mechanisms, such as chromatin remodeling complexes (INO80 [59,60], ISWI [61,62], and SWI/SNF [63,64,65]); histone post-translational modifications (PTMs) by histone acetyltransferases (HATs) [66], deacetylases (HDACs) [67], methyltransferases (HMTs) [68], and demethylases (HDMs) [69]; histone variants [70,71,72]; DNA [73,74,75] and RNA [76,77,78] methylation; plus non-coding [79,80,81,82], micro- [83,84,85], and circular [86,87,88] RNA. The gene discussed is SMARCA1; the disease is melanoma.