Despite some discrepancies in mechanisms and effector genes, LSD1, PRMT7, SETDB1, KDM5B, and ATF7IP functionally converge to evade melanoma immune clearance via repression of ancient genomic ERV elements that induce interferon signaling and translate immunogenic peptides for MHC-I presentation to CD8+ T cells (Table 1). The gene discussed is KDM5B; the disease is melanoma.