Furthermore, MITF activity depends on tumor microenvironment (TME) conditions, such as nutrient depletion [177,178], immune surveillance and inflammation [179,180,181], heterotypic interactions with normal cells [182], hypoxia [183,184], extracellular matrix (ECM) composition [185], and drug treatment [111,180,186,187]. The gene discussed is MITF; the disease is neoplasm.