BMI1 expression shifts melanoma to a metastatic state by inducing an invasive gene signature through WNT5A, ROR2, EGFR, and PDGFR, without a decrease in proliferation. WNT signaling maintains MITF expression, preventing proliferation defects typical of the invasive state, while concurrent EGFR and PDGFR upregulation maintains BRAFi resistance. BMI1 inhibition restored BRAFi sensitivity through WNT5A. The gene discussed is PDGFRB; the disease is melanoma.