Additionally, cyclin-dependent kinase 9 (CDK9) inhibition with toyocamycin activated the SWI/SNF catalytic subunit BRG1 and synergized with DNMT inhibition to de-repress endogenous retroviral elements and interferon signaling, sensitizing an in vivo ovarian cancer model to PD-1 immunotherapy [108,109]. Here, CDK9 is linked to ovarian carcinoma.