Microscopically, MM are characterized by nets composed of spindle-shaped cells [11] that express characteristically S–100, a typical calcium-binding protein [12,13], Melanoma Antigen (Melan–A), a melanocytic differentiation marker, and show positive reactivity for homatropine methyl bromide-45 (HMB–45) [10], a monoclonal antibody that interacts with GP-100. Here, PMEL is linked to Miyoshi myopathy.