DLBCL with MYC alteration is classified as (1) high-grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements (double/triple-hit lymphoma; DHL/THL), (2) DLBCL with MYC rearrangement (single-hit lymphoma; SHL), and (3) DLBCL with MYC-cluster amplification (MCAD). The gene discussed is BCL2; the disease is diffuse large B-cell lymphoma.