In the International Consensus Classification of Mature Lymphoid Neoplasms by Campo E et al. [44], The high-grade B-cell lymphomas (HGBCL-DH) now comprise two groups: HGBCL with MYC and BCL2 rearrangements (with or without BCL6 rearrangement) (HGBCL-DH-BCL2) and a new provisional entity, HBGBL with MYC and BCL6 rearrangements (HGBCL-DH-BCL6). The gene discussed is BCL6; the disease is B-cell non-Hodgkin lymphoma.