AKT1 and melanoma: Honokiol (34), a biphenolic compound isolated from Magnolia officinalis, acts as a potent inhibitor of melanoma B16-F10 cells by targeting melanoma stem cell signaling pathways by either suppressing NOTCH1 (notch receptor 1) signaling or increasing autophagosome formation, suggesting that honokiol (34) can also induce autophagy in melanoma cells via attenuating AKT-MTOR [233].