BECN1 is involved in autophagy induction and promotes tumor-suppressive functions by regulating UVRAG (UV radiation resistance associated) and SH3GLB1/Bif-1 (SH3 domain containing GRB2 like, endophilin B1) that positively regulates the activity of BECN1 via supporting the interplay between BECN1 and PIK3C3/VPS34, a component of the class III autophagy-specific phosphatidylinositol 3-kinase (PtdIns3K) complex, resulting in increased autophagy [85,86]. The gene discussed is BECN1; the disease is neoplasm.