A combination of resveratrol (32) and spermidine (44), a polyamine found in soybean and citrus fruit [249], triggers autophagy in human colon cancer HCT116 cells through AMPK-MTOR-independent pathways; although the major targets of resveratrol (32) and spermidine (44) are different, both factors activate converging pathways. Here, MTOR is linked to colonic neoplasm.