Diallyl disulfide, another component of garlic, was reported to induce apoptosis via the activation of CASP3, degradation of PARP, generation of hydrogen peroxide and fragmentation of DNA in human leukemia HL-60 cells [340] and via CASP3 activation in human bladder cancer T24 cells [341] and activation of pro-CASP9 and CASP3 in colorectal adenocarcinoma HT-29 cells, especially in combination with sodium butyrate [342]. The gene discussed is CASP3; the disease is colorectal adenocarcinoma.