A novel bioactive curcumin (33) analog (PAC: 3,5-Bis [4-hydroxy-3-methoxybenzylidene]-N-methyl-4-piperidone) suppresses cell survival and induces apoptosis in oral cancer Ca9-22 cells, involving MAPK1-MAPK3, MAPK14/p38-MAPK/JNK, NFKB, CASP3, CASP9 and WNT cellular signaling pathways [313]. Here, MAPK1 is linked to lip and oral cavity carcinoma.