AKT1 and leukemia: The taxane paclitaxel (17) induces apoptosis through the following: (a) control of AKT-MAPK and ROS signaling in canine mammary gland cancer cells [326]; (b) MAPK14/p38 pathway inhibition in paclitaxel-resistant ovarian cancer cells [327]; (c) activation of MAP3K5/Ask1-MAPK14/p38 and MAPK/JNK-MAPK/SAPK pathways and inhibition of AKT and MAPK1/ERK2-MAPK3/ERK1 in U-937 human macrophage cells [328]; (d) downregulation of NFKB and AKT in human ovarian cancer OVCAR-3 cells [329]; and (e) MAPK/JNK-MAPK/SAPK signaling pathway activation in glioblastoma U373MG and leukemia cells [328,330,331].