MYC and prostate cancer: It was found that camptothecin (5) enhances MYC/c-Myc expression, which in turn upregulates the expression of UPR sensor proteins in human prostate cancer (LNCaP cells), as well as reactive oxygen species (ROS) generation, which induces autophagy through the Ca2+-AMPK and MAPK/JNK-AP-1 signaling pathways [145].