AKT1 and prostate neoplasm: Moreover, resveratrol (32) triggers autophagy-mediated cell death in prostate tumor cells (PC3 and DU-145) through regulation of a store-operated calcium entry (SOCE) mechanism, including downregulating STIM1 (stromal interaction molecule 1) expression, which triggers ER stress and therefore activates AMPK and inhibits the AKT-MTOR pathway [201].