Curcumin (33) downregulates the expression of pro-apoptotic proteins BCL2 and BCL2L1, upregulates the expression of pro-apoptotic proteins BAX, BAK1, BBC3/PUMA and PMAIP1/NOXA and activates CASP3 and CASP9 in prostate cancer cells, which enhances the apoptosis-triggering ability of TNFRSF10A in androgen-unresponsive PC-3 cells and sensitized androgen-responsive TNFRSF10A-resistant LNCaP cells. Here, BBC3 is linked to Familial prostate cancer.