TP53 and gastric cancer: In addition, the impact of curcumin (33) on the proliferation, apoptosis and autophagy of GC cells (SGC-7901 and BGC-823) shows that this compound inhibits PI3K via downregulating the PI3K-AKT-MTOR pathway and activates the TP53 signaling pathway by upregulating TP53 and CDKN1A/p21, both of which regulate autophagy [230].