RUNX2 and thyroid tumor: Furthermore, in a comparison of TRβ1 and Runx2 expression in normal thyroid solid tissues, tumor adjacent normal thyroid tissues (NT) and thyroid tumor tissues (TP), we observed that the expression of TRβ1 was downregulated in thyroid tumor tissues (TP) compared to both normal thyroid tissues (GTEX) and tumor adjacent thyroid tissues (NT) (Figure 1G).