APS can also attenuate the metastasis of cervical cancer C33A cells and the migration and invasion of cervical cancer C-41 cells by inducing a reduction in matrix metalloproteinase 2 levels; metastasis of hepatocellular carcinoma H22 cells is inhibited by APS by down regulation of NOTCH1, while mouse Lewis lung cancer cells metastasis is attenuated through NF-κB and MAPK pathways inhibition [4,13,14,15,16,17]. The gene discussed is NOTCH1; the disease is cervical cancer.