We identified genes with a mean CCF more than two standard deviations from the mean per cancer type, and here we found that CYLD had a CCF significantly below average, indicating that it is more subclonal, in metastatic cancer in 6 cancer types (BLCA, BRCA, COAD, LUNG, PRAD and SKCM). Here, CYLD is linked to metastatic malignant neoplasm.