The specific mechanism is that F. nucleatum upregulates the binding efficiency of the transcription factor SP1 to the promoter region of lncRNA ENO1-IT1 to activate the transcription of lncRNA ENO1- IT1 and subsequently direct the histone acetyltransferase KAT7 to mediate histone modifications on lncRNA ENO1-IT1 target genes, including ENO1, thereby altering the biological function of CRC, including increasing lactate production, glucose uptake, and cell proliferation that is dependent on glycolysis [49]. Here, ENO1 is linked to colorectal carcinoma.