Subjects at high-risk of developing PDAC comprise individuals with new-onset diabetes mellitus [81,82,83,84,85,86,87], those with at least two first-degree relatives with PDAC, patients with (hereditary) chronic pancreatitis or defined predisposition syndromes (i.e., Peutz–Jeghers syndrome, those with germline pathogenic variants in CDKN2A, BRCA2, PALB2, or in the genes of the DNA mismatch repair system associated with Lynch syndrome) [88,89], or individuals with intraductal papillary mucinous neoplasms (IPMN) [90,91,92,93]. This evidence concerns the gene PALB2 and pancreatic intraductal papillary-mucinous neoplasm.