SNAI2 and neoplasm: In the same manner, intervening into the increase of miR-33a expression as a tumor suppressor at the cellular level with consequent downregulation of β-catenin, EMT-TFs (i.e., slug, vimentin, and N-cadherin) and of survivin, cyclin D1, and MDR-1 expression could mediate a greater sensitivity to GEM [135].