BRCA1 and neoplasm: The HR repair pathway is comprehensively modulated by proteins encoded by two classical tumor suppressor genes, BRCA1 and BRCA2, followed by the recruitment of RAD51, its paralogs (including RAD51B, RAD51C, RAD51D, XRCC2 and XRCC3) and RAD54 [6,41,42] to recognize a homologous DNA template and perform the strand invasion to repair DSBs.