A recent study has shown that IFN-α induces the differentiation and exhaustion of chronic myeloid leukemia and myeloproliferative neoplasm stem cells via the processes mediated by Cebpb, and IFN-α upregulates C/EBPβ by recruiting Stat1 and Stat5 to the novel 3′ distal enhancers of Cebpb [62]. The gene discussed is STAT1; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.