Based on their effectiveness in advanced stage cutaneous melanoma, immune checkpoint inhibitors (ICI), such as those blocking anti-cytotoxic T-lymphocyte-associated protein 4 (anti-CTLA-4) and/or programmed cell death-1 (PD-1)/programmed cell death ligand-1 PD-L1) are widely used in the treatment of MUM [9,10,11]. Here, CD274 is linked to cutaneous melanoma.