When Hilpert et al. examined CLL cells for NKG2D ligand expression (MICA, MICB, ULBP1, ULBP2, ULBP3), they found that 85% of CLL patients expressed at least one ligand, and most expressed more than one; however, when Veuillen et al. compared these to normal B cells, they found only ULBP3 to be upregulated [97,110]. Here, ULBP3 is linked to B-cell chronic lymphocytic leukemia.