These include decreasing CLL IL-10 production [193,195] and PD-L1 expression [195], decreasing Tregs [160,193,196] and MDSCs [160], altering T cell function and populations [193,197,198,199], altering monocyte/macrophage activity [200], and altering systemic cytokine levels [198]. Here, CD274 is linked to B-cell chronic lymphocytic leukemia.