HNF4A and hepatocellular carcinoma: WNT7B knockdown decreased TOP/FOP luciferase activity in HCCLM3 cells by 32.1% (pSilencer-WNT7B#1; p < 0.0001) and 25.9% (pSilencer-WNT7B#2; p < 0.001) compared to the pSilencer-NC control (Figure 3B), indicating that WNT7B can up-regulate CTNNB1/TCF-dependent transcriptional activation in HCC cells.