NOTCH1 and acute lymphoblastic leukemia: Of note, functional repression of the Notch pathway was further confirmed by the transcriptional inhibition of the Notch target gene DELTEX1, and both the receptors NOTCH1 and NOTCH3 upon exposure to curcumin in the T-ALL cells, except for NOTCH1 in DND41, which did not undergo significant alterations (Figure 1b).