TP53 and neoplasm: Curcumin’s anti-tumor activity has been linked to the modulation of a wide range of pro-survival signaling pathways, such as nuclear factor-ĸB (NF-ĸB), p53, Wnt/β-catenin, phosphoinositide 3-kinase/protein kinase B (PI3-Kinase/AKT), activator protein 1 (AP-1), and mitogen-activated protein kinase (MAPK) pathways [80].