AKT1 and osteosarcoma: Interestingly, the anti-growth effects of curcumin and its derivatives are correlated with the repression of Notch1 signaling and its interacting pathways in some solid cancers, including osteosarcoma [81], prostate cancer [82], hepatocellular carcinoma [83], and glioblastoma [39], while in T-ALL, its anti-leukemic activity has been mainly linked to mitochondrial Ca2+ overload, reactive oxygen species (ROS) induction, and (PI3K)/AKT pathway inhibition, which lead to cell-cycle disruption and caspase-dependent apoptotic cell death.