AKT1 and acute lymphoblastic leukemia: Nonetheless, the effectiveness of curcumin on Notch is under-explored in T-ALL; its anti-leukemic activity has mostly been linked to mitochondrial Ca2+ overload, ROS induction, and (PI3K)/AKT pathway inhibition that lead to cell cycle disruption and apoptotic cell death induction [40,41,62,63].