PARP1 and acute lymphoblastic leukemia: We detected decreased expression of N1Val in KOPT-K1 and DND41 cells and N3IC in TALL1 cells and observed increased levels of pH2AX and cleavage of PARP in a dose-dependent manner at micromolar concentrations around the respective IC50s, starting from the minimal dosage of the compound in the three T-ALL cell lines (Figure 1a).