Up-regulated miR-21 directly down-regulated programmed cell death 4 (PDCD4), a tumor suppressor [77,78]; inhibition of PDCD4 suppressed downstream E-cadherin expression and promoted β-catenin/TCF-dependent transcription of c-Myc and plasminogen activator, urokinase receptor (uPAR). This evidence concerns the gene PDCD4 and neoplasm.