They identified 997 Cd-induced differential genes potentially regulated by epigenetic mechanisms, and 400 of them were further validated in a large-scale breast cancer cohort, among which thioredoxin reductase 1 (TXNRD1) and chaperonin-containing TCP1 subunit 3 (CCT3) were identified as the critical genes that might play an important role in Cd-induced carcinogenesis [179]. The gene discussed is TXNRD1; the disease is breast carcinoma.