SHPRH and cancer: Mechanistically, circ-SHPRH functioned as a sponge of miR-224-5p; suppressed circ-SHPRH led to up-regulated miR-224-5p and resultant down-regulation of QKI (QKI, KH domain containing RNA binding), a direct target of miR-224-5p and a tumor-suppressor protein known to prevent proliferation and EMT during the progression of human cancers [234,235], promoting Cd-induced tumorigenesis [218].