PDCD4 and neoplasm: Furthermore, quercetin, an antioxidant flavonoid widely present in fruits and vegetables, inhibited Cr(VI)-induced activation of miR-21/PDCD4 cascade in BEAS-2B cells by decreasing ROS generation; quercetin therefore inhibited Cr(VI)-induced malignant transformation and suppressed the growth of xenograft tumor of Cr(VI)-transformed cells, suggesting a preventive and therapeutic role of quercetin in Cr(VI)-caused lung cancer [78].