Furthermore, we found that PD-L1 plasma concentration could hold a prognostic value in patients with an active GIST, as the patients with the highest plasma concentrations of PD-L1 (>225 pg/mL) had a poorer prognosis compared to patients having a lower plasma PD-L1 concentration (≤225 pg/mL). The gene discussed is CD274; the disease is gastrointestinal stromal tumor.