Treatment with the PB-020 (1 μM) /MBZ (0.25 μM) combination for 72 h additively decreased the levels of both IGF-1R and pIGF-1R in HT-29 and LoVo cells, but not the other three CRC lines (Figure 2A and Figure S6A). The gene discussed is IGF1R; the disease is colorectal carcinoma.