AKT1 and cancer: The PB-020/MBZ combination potently reduced the level of activated pAKT1-S473 protein, as maximal activation of AKT requires phosphorylation of S473 in the hydrophobic motif in multiple solid tumors [39] and the potent inhibitory effect of PB-020 and MBZ on pAKT1-S473 holds therapeutic potential for treating CRC and other cancers.