SIK1 and non-small cell lung carcinoma: Upon generating by CRISPR a KO per each of the 14 kinases known to be activated by LKB1, plus some combinations including the restore of LKB1 expression in NSCLC LKB1-null A549 cells, SIK1 alone and SIK1/SIK3 knock-outs resulted with the ability to recapitulate almost in full the LKB1-null features, and the complementary in vivo study confirmed and further characterized the impact that those two kinases have on LKB1-dependent signaling [43].