Activated second messengers, such as phosphorylated Met, p38, Akt, ERK and Jnk, were reduced upon KO of HGF, and upon exposure of WT HCC cell lines to H2O2 showed a greater resistance to apoptosis, highlighting the role of HGF autocrine signalling not just on cell proliferation [34]. This evidence concerns the gene HGF and hepatocellular carcinoma.