Thus, in a recent study, the generation of SOX10 knockout (SOX10-KO) in MITF methylated melanoma cell has shown that SOX10-KO cells revert to a pre-neural crest state characterized by the downregulation of SOX2, SOX5, SOX8, SNAI2 and increased expression of SOX9 [102]. Here, SOX10 is linked to melanoma.