In glioblastoma multiforme (GBM) cell lines, CRISPR/Cas9 genome editing technique led to identify different apoptosis-correlated genes: ERN1, IGFBP3, IGFBP5, FAT1, CHAF1A, GLI1, TRIM45, RGS4, ATM, PDPN, ATG5, ATG7, C14-IP-3. This evidence concerns the gene IGFBP5 and glioblastoma.