GLI1 (human glioma-associated oncogene homolog 1) is a key driver of PC metastasis [52] and is directly involved in the transcription of hepatocyte growth factor (HGF), insulin-like growth factor 1 (IGF-1), etc, which in turn can induce oncogenic signaling pathways such as NF-κB, and WNT/β-catenin signaling [53]. This evidence concerns the gene IGF1 and pachyonychia congenita.