TP53 and viral infectious disease: The p53 protein is considered one of the main regulators of the cell cycle as it is stabilized and activated following different cellular stresses, such as ionizing radiation (e.g., γ-rays), electromagnetic radiation (e.g., ultraviolet radiation), biological stresses (viral infections or bacterial toxins), chemical stresses, (toxic substances), endogenous stresses (high production of ROS, reactive oxygen species, which are highly damaging to all cellular structures), hypoxia or uncontrolled activation of oncogenes [20].