When the cells are hypoxic, PHDs are inactivated, this leads to HIF-1α stabilization and translocation to the nucleus, where it forms a dimer with HIF-1β and binds and promotes the expression of genes involved in a series of cellular responses, including survival, cell death, metabolic reprogramming, angiogenesis, stemness, inflammation, metastasis, immune evasion, etc., that is, genes that help tumor cells to adapt to the hypoxic environment and contribute to tumor progression [13,14]. Here, ARNT is linked to neoplasm.