CD8A and neoplasm: Besides targeting tumor cells, platinum compounds can also elicit an immune response against cancer cells through different mechanisms, i.e., by augmenting CD8+ T cells tumor infiltration, inducing maturation of Antigen-presenting cells (APCs), by downmodulating regulatory T cells (Tregs) and decreasing Myeloid-derived suppressor cells (MDSCs) which compose the so-called ‘immune permissive environment’ [45,46].