TLK1-driven motility promotion of PCa cells was a novel finding from our lab, although it was known that TLK2, a closely related kinase of TLK1 (both shares 96% homology in their kinase domain and 84% overall homology), can increase the migration and invasion of breast cancer and glioblastoma cell lines [19,20]. This evidence concerns the gene TLK2 and glioblastoma.