TLK1 and posterior cortical atrophy: We previously demonstrated that a serine/threonine (S/T) protein kinase, Tousled-like kinase 1 (TLK1), could promote PCa cell motility and clinical aggressiveness by phosphorylating another S/T kinase, MAPK-activated protein kinase 5 (MAPKAPK5/MK5) [7,8].