TLK1 and posterior cortical atrophy: This is particularly important in PCa, as androgen-deprivation therapy (ADT) translationally upregulates TLK1B (a spliced variant of TLK1 with intact kinase domain as TLK1) through the activation of the AKT > mTORC1 > 4EBP1 > eIF4E pathway (reviewed in Reference [9]).