Denosumab, a human-derived monoclonal antibody targeting RANKL, competes with RANK on the osteoclast surface for RANKL binding, effectively and safely inhibiting bone resorption and reducing the risk of SREs in postmenopausal women with osteoporosis and bone metastasis from multiple myeloma or breast cancer [179,180]. The gene discussed is TNFSF11; the disease is breast carcinoma.