CD4 and neoplasm: In contrast, CD8+ T cells derived from the mouse bone marrow microenvironment express the antiosteoclastic cytokines IFN-γ and IL-10 at high levels, and CD8+ FoxP3+ Treg cells derived from bone marrow inhibited the tumor-specific CD4+ T-cell phenotype before the arrival of tumor cells in bone marrow in an orthotopic mouse model, exerting a protective effect during the maintenance of bone homeostasis [139].