When the bone matrix is dissolved, numerous bone-related factors, such as TGF-β, IGFs, fibroblast growth factors (FGFs), platelet-derived growth factor (PDGF), and bone morphogenetic proteins (BMPs), are released, to promote the growth and division of tumor cells, forming a vicious cycle of tumor-induced bone destruction [17]. Here, TGFB1 is linked to neoplasm.